59. Miao Xie, Fujun Wang, Jiapei Yang, Yuanyuan Guo, Fei Ding, Xinmiao Lu, Yangyang Huang, Yimeng Li, Xinyuan Zhu*, Chuan Zhang*, “DNA Zipper Mediated Membrane Fusion for Rapid Exosomal miRNA Detection”, Analytical Chemistry, 2022, 94, 13043-13051.
58. Huan Ge, Donglei Yang*, Yimeng Li, Yongji Wei, Xinyuan Zhu, Pengfei Wang*, Chuan Zhang*, “A Reconfigurable Nanophotonic Heterostructure Engineered by a DNA Origami Switch”, ChemPlusChem, 2022, 87, e202200229.
57. Yucheng Fu, Guoyu He, Zhuochao Liu, Jun Wang, Meng Li, Zhusheng Zhang, Qiyuan Bao, Junxiang Wen, Xinyuan Zhu, Chuan Zhang*, Weibin Zhang*, “DNA Base Pairing-Inspired Supramolecular Nanodrug Camouflaged by Cancer-Cell Membrane for Osteosarcoma Treatment”, Small, 2022, 18, 2202337.
56. Yuanyuan Guo, Jingcan Qin, Qianqian Zhao, Jiapei Yang, Xiaoer Wei, Yu Huang, Miao Xie, Chuan Zhang*, Yuehua Li*, “Plaque-targeted rapamycin spherical nucleic acids for synergistic atherosclerosis treatment”, Adv. Sci., 2022, 16, e2105875.
55. Yuanyuan Guo, Qiushuang Zhang, Qiwen Zhu, Jing Gao, Xinyuan Zhu, Haijun Yu,* Yuehua Li,* Chuan Zhang*, “Co-packaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy”, Sci. Adv., 2022, 8, eabn2941.
54. Lijuan Zhu, Jiapei Yang, Yuan Ma, Xinyuan Zhu, Chuan Zhang*, “Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy”, J. Am. Chem. Soc., 2022, 144, 1493-1497.
53. Yuhe Liu, Jiao Zhang, Yuanyuan Guo, Ping Wang, Yue Su, Xin Jin, Xinyuan Zhu, Chuan Zhang*, “Drug-Grafted DNA as A Novel Chemogene for Targeted Combinatorial Cancer Therapy”, Exploration, 2022, 2, 20210172.
52. Xinlong Liu, Fei Ding, Yuanyuan Guo, Kai Jiang, Yucheng Fu, Lijuan Zhu, Ming Li, Xinyuan Zhu, Chuan Zhang*, “Complexing the Pre-Assembled Brush-Like siRNA with Poly(β-amino ester) for Efficient Gene Silencing”, ACS Appl. Bio Mater., 2022, 5, 1857-1867.
51. Yuan Ma, Quanbing Mou, Peng Yan, Zhenglin Yang, Ying Xiong, Deyue Yan, Chuan Zhang*, Xinyuan Zhu*, Yi Lu*,”A highly sensitive and selective fluoride sensor based on a riboswitch-regulated transcription coupled with CRISPR-Cas13a tandem reaction”, Chem. Sci., 2021, 12, 11740-11747.
50. Yiqing Ren, Xinlong Liu, Huan Ge, Yuanyuan Guo, Qiushuang Zhang, Miao Xie, Ping Wang, Xinyuan Zhu, Chuan Zhang*,”A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery”, Chemical Research in Chinese Universities, 2021, 37, 906-913.
49. Qiushuang Zhang, Yuanyuan Guo, Lijuan Zhu, Xinlong Liu, Jiapei Yang, Yuehua Li, Xinyuan Zhu*, Chuan Zhang*, “A nucleic acid nanogel dually bears siRNA and CpG motifs for synergistic tumor immunotherapy”, Biomaterials Science, 2021, 9, 4755-4764.
48. Xihui Gao, Sha Li, Fei Ding, Xinlong Liu, Yijing Wu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Virus-Mimicking Nucleic Acid Nanogel Reprograms the Microglia and Macrophage for Glioblastoma Therapy”, Adv. Mater., 2021, 33, 2006116.
47. Xiangang Huang, Nicholas Thomas Blum, Jing Lin, Jinjun Shi*, Chuan Zhang*, Peng Huang*,”Chemotherapeutic drug–DNA hybrid nanostructures for anti-tumor therapy”, Materials Horizons, 2021, 8, 78-101.
46. Xiangang Huang, Ru Zheng, Fei Ding, Jiapei Yang, Miao Xie, Xinlong Liu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Efficient Delivery of mRNA Using Crosslinked Nucleic Acid Nanogel as A Carrier”, ACS Mater. Lett., 2020, 2, 1509-1515.
45. Dongbo Guo, Yu Huang, Xin Jin*, Chuan Zhang, Xinyuan Zhu*, “A Redox-Responsive, In-Situ Polymerized Polyplatinum(IV)-Coated Gold Nanorod as An Amplifier of Tumor Accumulation for Enhanced Thermo-Chemotherapy”, Biomaterials, 2020, 266, 120400.
44. Yan Liu, Jin Cheng, Sisi Fan, Huan Ge, Tao Luo, Linlin Tang, Bin Ji, Chuan Zhang, Daxiang Cui, Yonggang Ke, Jie Song*, “Modular Reconfigurable DNA Origami: from 2D to 3D”, Angew. Chem. Int. Ed., 2020, 59, 23277-23282.
43. Qiushuang Zhang, Fei Ding, Xinlong Liu, Jian Shen*, Yue Su, Jiwen Qian, Xinyuan Zhu*, Chuan Zhang*, “Nanobody-guided targeted delivery of microRNA via nucleic acid nanogel to inhibit the tumor growth”, Journal of Controlled Release, 2020, 328, 425-434.
42. Sisi Fan, Jin Cheng, Yan Liu, Dongfang Wang, Tao Luo, Bin Dai, Chuan Zhang, Daxiang Cui, Yonggang Ke, Jie Song*, “Proximity-Induced Pattern Operations in Reconfigurable DNA Origami Domino Array”, J. Am. Chem. Soc., 2020, 142, 14566-14573.
41. Lijuan Zhu, Yuanyuan Guo, Qiuhui Qian, Deyue Yan, Yuehua Li, Xinyuan Zhu, Chuan Zhang*, “Carrier-Free Delivery of Precise Drug-Chemogene Conjugates for Synergistic Treatment of Drug-Resistant Cancer”, Angew. Chem. Int. Ed., 2020, 59, 17944-17950.
40. Yushuang Ren, Yuanyuan Guo, Xueyi Liu, Jie Song, Chuan Zhang*, “Platinum(IV) prodrug-grafted phosphorothioate DNA and its self-assembled nanostructure for targeted drug delivery”, Chemical Research in Chinese Universities, 2020, 41, 1721-1730.
39. Yuanyuan Guo, Jiao Zhang, Gaifang Pan, Chung Hang Jonathan Choi, Ping Wang, Yuehua Li, Xinyuan Zhu, Chuan Zhang*, “Grafting Multi-Maleimides on Antisense Oligonucleotide to Enhance Its Cellular Uptake and Gene Silencing Capability”, Chemical Communications, 2020, 56, 7439-7442.
38. Jiao Zhang, Yuanyuan Guo, Gaifang Pan, Ping Wang, Yuehua Li*, Xinyuan Zhu, Chuan Zhang*, “Injectable Drug-Conjugated DNA Hydrogel for Local Chemotherapy to Prevent Tumor Recurrence”, ACS Appl. Mater. Interfaces, 2020, 12, 21441-21449.
37. Huan Ge, Dongya Wang, Yue Pan, Yuanyuan Guo, Hongyu Li, Fan Zhang, Xinyuan Zhu, Yuehua Li, Chuan Zhang*, Ling Huang*, “Sequence-Dependent DNA Functionalization of Upconversion Nanoparticles and Their Programmable Assemblies”, Angew. Chem. Int. Ed., 2020, 59, 8133-8137.
36. Fei Ding, Xihui Gao, Xiangang Huang, Huan Ge, Miao Xie, Jiwen Qian, Jie Song, Yuehua Li*, Xinyuan Zhu, Chuan Zhang*, “Polydopamine-coated nucleic acid nanogel for siRNA-mediated low-temperature photothermal therapy”, Biomaterials, 2020, 245, 119976.
35. Sha Li, Yijing Wu, Fei Ding, Jiapei Yang, Jing Li, Xihui Gao*, Chuan Zhang*, Jing Feng*, “Engineering macrophage-derived exosomes for targeted chemotherapy of triple-negative breast cancer”, Nanoscale, 2020, 12, 10854-10862.
34. Travis A. Meyer, Chuan Zhang, Gang Bao, Yonggang Ke*, “Programmable Assembly of Iron Oxide Nanoparticles Using DNA Origami”, Nano Lett., 2020, 20, 2799-2805.
33. Dongbo Guo, Shuting Xu, Wumaier Yasen, Chuan Zhang*, Jian Shen*, Yu Huang, Dong Chen, Xinyuan Zhu*, “Tirapazamine-embedded polyplatinum (IV) complex: a prodrug combo for hypoxia-activated synergistic chemotherapy”, Biomaterials Science, 2020, 8, 694-701.
32. Gaifang Pan, Yuan Ma, Jiao Zhang, Yuanyuan Guo, Fei Ding, Huan Ge, Qifeng Li, Xinyuan Zhu, Chuan Zhang*, “Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery”, Chemical Research in Chinese Universities, 2019, 36, 274-280.
31. Gaifang Pan, Quanbing Mou, Yuan Ma, Fei Ding, Jiao Zhang, Yuanyuan Guo, Xiangang Huang, Qifeng Li, Xinyuan Zhu, Chuan Zhang*, “pH-Responsive and Gemcitabine-Containing DNA Nanogel to Facilitate the Chemodrug Delivery”, ACS Appl. Mater. Interfaces, 2019, 11, 41082-41090.
30. Fei Ding, Xiangang Huang, Xihui Gao, Miao Xie, Gaifang Pan, Qifeng Li, Jie Song, Xinyuan Zhu, Chuan Zhang*, “A Non-cationic Nucleic Acid Nanogel for the Delivery of CRISPR/Cas9 Gene Editing Tool”, Nanoscale, 2019, 11, 17211-17215 .
29. Jiao Zhang, Yuanyuan Guo, Fei Ding, Gaifang Pan, Xinyuan Zhu, and Chuan Zhang*, “Camptothecin-Grafted DNA Tetrahedron as Precise Nanomedicine to Inhibit the Tumor Growth”, Angew. Chem. Int. Ed., 2019, 58, 13794-13798.
28. Yuan Ma, Quanbing Mou, Lijuan Zhu, Yue Su, Xin Jin, Jing Feng, Deyue Yan, Xinyuan Zhu, and Chuan Zhang*, “Polygemcitabine nanogel with accelerated drug activation for cancer therapy”, Chemical Communications, 2019, 55, 6603-6606.
27. Xihui Gao, Sha Li, Fei Ding, Hongjia Fan, Leilei Shi, Lijuan Zhu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Rapid Detection of Exosomal microRNAs Using Virus-Mimicking Fusogenic Vesicles”, Angew. Chem. Int. Ed., 2019, 58, 8719-8723.
26. Quanbing Mou, Yuan Ma, Fei Ding, Xihui Gao, Deyue Yan, Xinyuan Zhu, and Chuan Zhang*, “Two-in-One Chemogene Assembled from Drug-Integrated Antisense Oligonucleotides to Reverse Chemoresistance”, J. Am. Chem. Soc., 2019, 141, 6955-6966.
25. Han Xue, Fei Ding, Jiao Zhang, Yuanyuan Guo, Xihui Gao*, Jing Feng, Xinyuan Zhu, and Chuan Zhang*, “DNA Tetrahedron-Based Nanogels for siRNA Delivery and Gene Silencing”, Chemical Communications, 2019, 55, 4222-4225.
24. Yuanyuan Guo, Jiao Zhang, Fei Ding, Gaifang Pan, Jing Li, Jing Feng, Xinyuan Zhu, and Chuan Zhang*, “Stressing the Role of DNA as Drug Carrier: Synthesis of the DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides”, Advanced Materials, 2019, 31, 1807533.
23. Han Xue, Xihui Gao, Chuan Zhang*, “DNA nanostructure-based siRNA delivery systems”, Chinese Science Bulletin, 2019, 64: 1053-1066 (the original version is in Chinese)
22. Tiantian Man, Wei Ji, Xiaoguo Liu, Chuan Zhang*, Li Li, Hao Pei*, Chunhai Fan*, “Chiral Metamolecules with Active Plasmonic Transition”, ACS Nano, 2019, 13, 4826-4833.
21. Lei Zhang, Xiaoyu Tian, Cecilia K. W. Chan, Chak Kwong Cheng, Francis M. Chen, Maggie S. H. Cheung, Bohan Yin, Hongrong Yang, Wing Yin Yung, Zhong Chen, Ken Cham-Fai Leung, Chuan Zhang, Joyce M. S. Chan, Yu Huang, James Y. W. Lau, Chung Hang Jonathan Choi*, “Promoting the delivery of nanoparticles to atherosclerotic plaques by DNA coating”, ACS Appl. Mater. Interfaces, 2019, 11, 13888-13904.
20. Leilei Shi, Qinghua Guan, Xihui Gao, Xin Jin, Li Xu, Jian Shen*, Chenwei Wu, Xinyuan Zhu, and Chuan Zhang*, “Reaction Based Color-Convertible Fluorescent Probe for Ferroptosis Identification”, Analytical Chemistry, 2018, 90, 9218-9225.
19. Chenwei Wu, Li Xu, Leilei Shi, Xihui Gao, Jing Li, Xinyuan Zhu*, Chuan Zhang*, “Supramolecularly self-assembled nano-twin drug to reverse the multidrug resistance”, Biomaterials Science, 2018, 6, 2261-2269.
18. Dongbo Guo, Shuting Xu, Yu Huang, Huangyong Jiang, Wumaier Yasen, Nan Wang, Yue Su, Jiwen Qian, Jing Li, Chuan Zhang*, Xinyuan Zhu, “Platinum(IV) Complex-Based Two-in-One Polyprodrug for A Combinatorial Chemo-Photodynamic Therapy”, Biomaterials, 2018, 177，67-77.
17. Shuting Xu, Xinyuan Zhu, Chuan Zhang, Wei Huang, Yongfeng Zhou, Deyue Yan*, “Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor”, Nature Communications, 2018, DOI: 10.1038/s41467-018-04318-1.
16. Ma Y., Liu H., Mou Q., Yan D., Zhu X., Zhang C.* “Floxuridine-Containing Nucleic Acid Nanogels for Anticancer Drug Delivery”, Nanoscale, 2018, 10, 8367 – 8371.
15. Shi L., Gao X., Yuan W., Xu L., Deng H., Wu C., Yang J., Jin X.*, Zhang C.*, Zhu X., “Endoplasmic Reticulum Targeted Fluorescent Nanodot with Large Stokes Shift for Vesicular Transport Monitoring and Long-Term Bioimaging”, Small, 2018, 14, 1800223.
14. Yu H., Man T., Ji W., Shi L., Wu C., Pei H.*, Zhang C.*, “Controllable self-assembly of parallel gold nanorod clusters by DNA origami”, Chinese Chemical Letters, 2018, 30, 175-178.
13. Ding F., Mou Q., Ma Y., Pan G., Guo Y., Tong G., Choi C. H. J., Zhu X., Zhang C.*, “Crosslinked Nucleic Acid Nanogel For Effective siRNA Delivery and Antitumor Therapy”, Angew. Chem. Int. Ed., 2018, 57, 3064-3068.
12. Wang D., Lu X., Jia F., Tan X., Sun X., Cao X., Wai F., Zhang C.*, Zhang K.*, “Precision Tuning of DNA- and Poly(ethylene glycol)-Based Nanoparticles via Coassembly for Effective Antisense Gene Regulation“, Chem. Mater.,2017, 29, 9882–9886.
11. Mou Q., Ma Y., Pan G., Xue B., Yan D., Zhang C.*, Zhu X.*, “DNA Trojan Horses: The Self-Assembled Floxuridine-Containing DNA Polyhedra for Cancer Therapy”, Angew. Chem. Int. Ed., 2017, 56, 12528–12532.
10. Wang D., Liu B., Ma Y., Wu C., Mou Q., Deng H., Wang R., Yan D., Zhang C.*, Zhu X.*, “A molecular recognition approach to synthesize nucleoside analogue based multifunctional nanoparticles for targeted cancer therapy”, J. Am. Chem. Soc., 2017, 139, 14021-14024.
9. Pan G., Jin X., Mou Q.*, Zhang C.*, “Recent progress on DNA block copolymer”, Chinese Chemical Letters, 2017, 28, 1822-1828.
8. Wu X., Wu C., Ding F., Tian C., Jiang W, Mao C.*, Zhang C.*, “Binary self-assembly of highly symmetric DNA nanocages via sticky-end engineering”, Chinese Chemical Letters, 2017, 28, 851-856.
7. Xu L., Yang J., Xue B., Zhang C.*, Shi L., Wu C., Su Y., Jin X., Liu Y.*, Zhu X.*, “Molecular insights for the biological interactions between polyethylene glycol and cells”, Biomaterials, 2017, 147, 1-13.
6. Guo D., Xu S., Wang N., Jiang H., Huang Y., Jin X., Xue B., Zhang C.*, Zhu X.*, “Prodrug-embedded angiogenic vessel-targeting nanoparticle: A positive feedback amplifier in hypoxia-induced chemo-photo therapy”, Biomaterials, 2017, 144, 188-198.
5. Li C., Pan R., Li P.*, Guan Q., Ao J., Wang K., Xu L., Liang X., Jin X., Zhang C.*, Zhu X.*, A hydrogen peroxide-responsive nanoprobe assists circulating tumor cell identification and colorectal cancer diagnosis, Analytical Chemistry, 2017, 89, 5966-5975.
4. Wu X. Wu C., Zhang C.*, DNA Three-dimensional Nanostructures: The Synthesis and Applications, Chinese Journal of Polymer Science, 2017, 35, 1-24 (invited review).
3. Yi Hu, Leilei Shi, Yue Su*, Chuan Zhang, Xin Jin, Xinyuan Zhu*, “A fluorescent light-up aggregation-induced emission probe for screening gefitinib-sensitive non-small cell lung carcinoma”, Biomaterials Science, 2017, 5, 792-799.
2. Shi L., Hu Y., Lin A., Ma C., Zhang C.*, Su Y., Zhou L., Niu Y., Zhu X.*, Matrix Metalloproteinase Responsive Nanoparticles for Synergistic Treatment of Colorectal Cancer via Simultaneous Anti-Angiogenesis and Chemotherapy，Bioconjugate Chemistry, 2016, 27, 2943-2953.
1. Wang, D., Tu, C., Su, Y., Zhang, C., Greiser, U., Zhu, X., Yan, D., Wang, X., Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery. Chemical Science, 2015, 6, 3775-3787.
Selected Publications Before Joining the SJTU
16. Zhang C., Hao L, Calabrese CM, Choi CHJ, Zhou Y, Mirkin C. A. Biodegradable DNA-brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation. Small, 11, 5360-5368 (2015).
15. Park D. J., Zhang C., Ku J. C., Zhou Y., Schatz G. C., Mirkin C. A., “Plasmonic photonic crystals realized through DNA-programmable assembly”, Proc. Natl. Acad. Sci. USA, 112: 977-981 (2015).
14. Zhang C., Li X., Tian C., Li. Y., Jiang W., Mao C.D., “DNA Nanocages Swallow Gold Nanoparticles (AuNPs) to Form AuNP@DNA Cage Core-Shell Structures”, ACS Nano. 8, 1130–1135 (2014).
13. Zhang C., Macfarlane R. J., Young K. L., Choi C. H. J., Hao L., Auyeung E., Liu G., Zhou X., Mirkin C. A., “A General Approach to DNA-Programmable Atom Equivalents”, Nat. Mater., 12, 741-746 (2013).
Also see: Simon U. “Nanoparticle self-assembly: Bonding them all”. Nat. Mater. 12, 694 (2013). Highlighted by C&EN, 21, 41 (2013).
12. Zhang C., Tian C., Li X., Qian H., Hao C., Wang G., Jiang W., Mao C.D., “Reversibly Switching the Surface Porosity of a DNA Tetrahedron”, J. Am. Chem. Soc., 134, 11998-12001 (2012).
11. Zhang C., Wu W.M., Li X., Tian C., Qian H., Wang G., Jiang W., Mao C.D., “Controlling the Chirality of DNA Nanocages”, Angew. Chem. Int. Ed., 51, 7999-8002 (2012).
10. Zhang C., Tian C., Guo F., Liu Z., Jiang W., Mao C.D., “DNA-Directed Three Dimensional (3D) Protein Organization”, Angew. Chem. Int. Ed., 51, 3382-3385 (2012).
9. Zhang C., He Y., Leng Y. J., Ribbe A.E., Jiang W., Mao C.D., “Exterior modification of a DNA tetrahedron”, Chem Comm.. 46, 6792-6794 (2010).
8. Zhang C., Ko S. H., Su M., Leng Y. J., Ribbe A.E., Jiang W., Mao C.D., “Symmetry Controls the Face Geometry of DNA Polyhedra”, J. Am. Chem. Soc., 131: 1413-1415 (2009).
7. Zhang C., He Y., Mao C.D., “A Brief Review: DNA Nanocages Self-assembled by Star-shaped DNA Motifs”, Faraday Discuss., 143, 221-233 (2009).
6. Zhang C., Mao C.D., “DNA Nanotechnology: Bacteria as factories”, Nat. Nanotech., 3: 707-708 (2008).
5. Zhang C., Su M., He Y., Zhao X., Fang P.A., Ribbe A.E., Jiang W., Mao C.D.; “Conformational Flexibility Facilitates Self-Assembly of Complex DNA Nanostructures”, Proc. Natl. Acad. Sci. USA, 105: 10665-10669 (2008).
4. He Y., Ye T., Su M., Zhang C., Ribbe A.E., Jiang W., Mao C.D., “Hierarchical Self-assembly of DNA into Symmetric Supramolecular Polyhedra”, Nature, 452: 198-201 (2008).
3. Zhang C., He Y., Chen Y., Ribbe A.E., Mao C.D.; “Aligning One-dimensional DNA Duplexes into Two-dimensional Crystals” J. Am. Chem. Soc., 129: 14134-14135 (2007).
2. Zhang C., Zhu Y.F., “Synthesis of Square Bi2WO6 Nanoplates as High Activity Visible-Light-Driven Photocatalysts”, Chem. Mater., 17: 3537-3545 (2005).
1. Zhang C., Wang L., Cui L.P., Zhu Y.F., “A Novel Method for The Synthesis of Nano-sized BaAl2O4 with Thermal Stability”, J. Cryst. Growth., 255: 317-323 (2003).
Research on Nucleic Acid Based Supramolecular Chemistry 